Spinal cord stimulation (SCS) is a well-established therapy to relieve pain in subjects with chronic pain. In this therapy, electrical currents are delivered to the dorsal column (DC) of the spinal cord via electrodes implanted in the epidural space. However, despite its widespread and long use, SCS is still prone to failures and there remain opportunities to improve its clinical efficacy. In this project, we will develop computational models to analyze an alternative modality of SCS in which the currents are delivered via skin electrodes, thereby overcoming the main failure factors of epidural SCS, and avoiding the risks and costs associated with the surgical requirements of implanted devices.
BACKGROUND Incorporating kilohertz-frequency signals in transcutaneous electrical stimulation has been proposed as a means to overcome the impedance of the skin, thereby reaching deeper nerves. In particular, a transdermal amplitude modulated signal …
OBJECTIVE: Incorporating high-frequency components in transcutaneous electrical stimulation (TES) waveforms may make it possible to stimulate deeper nerve fibers since the impedance of tissue declines with increasing frequency. However, the …
Electrical stimulation of peripheral nerves is a widespread technique for the treatment of neurological diseases and disorders. However, peripheral stimulation typically requires surgical implantation of an electrode and a pulse generator. …