Spinal cord stimulation (SCS) is a well-established therapy to relieve pain in subjects with chronic pain. In this therapy, electrical currents are delivered to the dorsal column (DC) of the spinal cord via electrodes implanted in the epidural space. However, despite its widespread and long use, SCS is still prone to failures and there remain opportunities to improve its clinical efficacy. In this project, we will develop computational models to analyze an alternative modality of SCS in which the currents are delivered via skin electrodes, thereby overcoming the main failure factors of epidural SCS, and avoiding the risks and costs associated with the surgical requirements of implanted devices.
Introduction: Kilohertz-frequency spinal cord stimulation (KHF-SCS) was recently proposed as a paresthesia-free treatment for persons with chronic pain that is potentially more effective than conventional (~ 50 Hz) SCS. In SCS, the applied electrical …
BACKGROUND Incorporating kilohertz-frequency signals in transcutaneous electrical stimulation has been proposed as a means to overcome the impedance of the skin, thereby reaching deeper nerves. In particular, a transdermal amplitude modulated signal …
Introduction Kilohertz-frequency spinal cord stimulation (KHF-SCS) was recently proposed as a paresthesia-free treatment for persons with chronic pain that is potentially more effective than conventional (̃50 Hz) SCS. In SCS, the applied electrical …
Mainstream electrical stimulation therapies, e.g., spinal cord stimulation (SCS) and deep brain stimulation, use pulse trains that are delivered at rates no higher than 200 Hz. In recent years, stimulation of nerve fibers using kilohertz-frequency …
Objective. Models of excitable cells consider the membrane specific capacitance as a ubiquitous and constant parameter. However, experimental measurements show that the membrane capacitance declines with increasing frequency, i.e., exhibits …
textcopyright 2015 IEEE. Transcutaneous electrical stimulation (TES) of nerve fibers may be optimized by overcoming the impedance of the skin using high-frequency (HF) stimulation signals. The excitation properties of nerve fibers depend on the …
OBJECTIVE: Incorporating high-frequency components in transcutaneous electrical stimulation (TES) waveforms may make it possible to stimulate deeper nerve fibers since the impedance of tissue declines with increasing frequency. However, the …